A case report of intramyocardial bridge on right coronary artery

Los puentes intramiocárdicos son una anomalía de la circulación coronaria. Estos suelen presentarse en el trayecto de la arteria descendente anterior y se clasifican en superficiales o profundos. Reportamos el hallazgo de un puente intramiocárdico en el trayecto de la arteria coronaria derecha, incluida su rama sinoauricular y descendente posterior durante la disección de rutina de un cadáver. El paciente al parecer no presentó signos relativos a insuficiencia coronaria y falleció debido a una insuficiencia respiratoria aguda causada por neumonía aspirativa. Debido a la presencia limitada de casos sobre puente intramiocárdico de la arteria coronaria derecha, realizamos una revisión de la literatura al respecto y planteamos algunas conclusiones

CARAMEL: results on a secure architecture for connected and autonomous vehicles detecting GPS spoofing attacks

The main goal of the H2020-CARAMEL project is to address the cybersecurity gaps introduced by the new technological domains adopted by modern vehicles applying, among others, advanced Artificial Intelligence and Machine Learning techniques. As a result, CARAMEL enhances the protection against threats related to automated driving, smart charging of Electric Vehicles, and communication among vehicles or between vehicles and the roadside infrastructure. This work focuses on the latter and presents the CARAMEL architecture aiming at assessing the integrity of the information transmitted by vehicles, as well as at improving the security and privacy of communication for connected and autonomous driving. The proposed architecture includes: (1) multi-radio access technology capabilities, with simultaneous 802.11p and LTE-Uu support, enabled by the connectivity infrastructure; (2) a MEC platform, where, among others, algorithms for detecting attacks are implemented; (3) an intelligent On-Board Unit with anti-hacking features inside the vehicle; (4) a Public Key Infrastructure that validates in real-time the integrity of vehicle’s data transmissions. As an indicative application, the interaction between the entities of the CARAMEL architecture is showcased in case of a GPS spoofing attack scenario. Adopted attack detection techniques exploit robust in-vehicle and cooperative approaches that do not rely on encrypted GPS signals, but only on measurements available in the CARAMEL architecture.This work was supported by the European Union’s H2020 research and innovation programme under the CARAMEL project (Grant agreement No. 833611). The work of Christian Vitale, Christos Laoudias and Georgios Ellinas was also supported by the European Union’s Horizon 2020 Research and Innovation Programme under Grant 739551 (KIOS CoE) and from the Republic of Cyprus through the Directorate General for European Programmes, Coordination, and Development. The work of Jordi Casademont and Pouria Sayyad Khodashenas was also supported by FEDER and Secretaria d’Universitats i Recerca del Departament d’Empresa i Coneixement de la Generalitat de Catalunya through projects Fem IoT and SGR 2017-00376 and by the ERDFPeer ReviewedPostprint (author's final draft

Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients

Clear differences have been established between head and neck squamous cell carcinomas (HNSCC) depending on human papillomavirus (HPV) infection status. This study specifically investigated the status of the CTTN, CCND1 and ANO1 genes mapping at the 11q13 amplicon in relation to the HPV status in HNSCC patients. CTTN, CCND1 and ANO1 protein expression and gene amplification were respectively analyzed by immunohistochemistry and real-time PCR in a homogeneous cohort of 392 surgically treated HNSCC patients. The results were further confirmed using an independent cohort of 279 HNSCC patients from The Cancer Genome Atlas (TCGA). The impact on patient survival was also evaluated. CTTN, CCND1 and ANO1 gene amplification and protein expression were frequent in HPV-negative tumors, while absent or rare in HPV-positive tumors. Using an independent validation cohort of 279 HNSCC patients, we consistently found that these three genes were frequently co-amplified (28%) and overexpressed (39-46%) in HPV-negative tumors, whereas almost absent in HPV-positive tumors. Remarkably, these alterations (in particular CTTN and ANO1 overexpression) were associated with poor prognosis. Taken together, the distinctive expression and amplification of these genes could cooperatively contribute to the differences in prognosis and clinical outcome between HPV-positive and HPV-negative tumors. These findings could serve as the basis to design more personalized therapeutic strategies for HNSCC patients

Re-cognizing the new self: The neurocognitive plasticity of self-processing following facial transplantation.

The face is a defining feature of our individuality, crucial for our social interactions. But what happens when the face connected to the self is radically altered or replaced? We address the plasticity of self-face recognition in the context of facial transplantation. While the of a new face following facial transplantation is a medical fact, the of a new identity is an unexplored psychological outcome. We traced the changes in self-face recognition before and after facial transplantation to understand if and how the transplanted face gradually comes to be perceived and recognized as the recipient's own new face. Neurobehavioral evidence documents a strong representation of the pre-injury appearance pre-operatively, while following the transplantation, the recipient incorporates the new face into his self-identity. The acquisition of this new facial identity is supported by neural activity in medial frontal regions that are considered to integrate psychological and perceptual aspects of the self

Effects of different doses of high-speed resistance training on physical performance and quality of life in older women: a randomized controlled trial.

Objective: This study aimed to compare the effects of two frequencies of high-speed resistance training (HSRT) on physical performance and quality of life of older women. Methods: A total of 24 older women participated in a 12-week HSRT program composed of either two or three sessions/week (equated for volume and intensity). Women were randomized into three arms: a control group (CG, n=8), a resistance training group performing two sessions/week (RT2, n=8), and a resistance training group performing three sessions/week (RT3, n=8). The training program for both experimental groups included exercises that required high-speed concentric muscle actions. Results: No baseline differences were observed among groups. Compared with the CG, both training groups showed similar small to moderate improvements (P<0.05) in muscle strength, power, functional performance, balance, and quality of life. Conclusion: These results suggest that equated for volume and intensity, two and three training sessions/week of HSRT are equally effective for improving physical performance and quality of life of older women

Integration of contractile forces during tissue invagination

Contractile forces generated by the actomyosin cytoskeleton within individual cells collectively generate tissue-level force during epithelial morphogenesis. During Drosophila mesoderm invagination, pulsed actomyosin meshwork contractions and a ratchet-like stabilization of cell shape drive apical constriction. Here, we investigate how contractile forces are integrated across the tissue. Reducing adherens junction (AJ) levels or ablating actomyosin meshworks causes tissue-wide epithelial tears, which release tension that is predominantly oriented along the anterior–posterior (a-p) embryonic axis. Epithelial tears allow cells normally elongated along the a-p axis to constrict isotropically, which suggests that apical constriction generates anisotropic epithelial tension that feeds back to control cell shape. Epithelial tension requires the transcription factor Twist, which stabilizes apical myosin II, promoting the formation of a supracellular actomyosin meshwork in which radial actomyosin fibers are joined end-to-end at spot AJs. Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis.American Cancer Society (grant PF-06-143-01-DDC)National Institutes of Health (U.S.) (NIH/NIGMS, P50 grant GM071508)National Institutes of Health (U.S.) (NIH/NIGMS, R01 grant GM079340)Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (grant 5R37HD15587)Howard Hughes Medical Institute (Investigator

ELECTRON: An Architectural Framework for Securing the Smart Electrical Grid with Federated Detection, Dynamic Risk Assessment and Self-Healing

The electrical grid has significantly evolved over the years, thus creating a smart paradigm, which is well known as the smart electrical grid. However, this evolution creates critical cybersecurity risks due to the vulnerable nature of the industrial systems and the involvement of new technologies. Therefore, in this paper, the ELECTRON architecture is presented as an integrated platform to detect, mitigate and prevent potential cyberthreats timely. ELECTRON combines both cybersecurity and energy defence mechanisms in a collaborative way. The key aspects of ELECTRON are (a) dynamic risk assessment, (b) asset certification, (c) federated intrusion detection and correlation, (d) Software Defined Networking (SDN) mitigation, (e) proactive islanding and (f) cybersecurity training and certification